The inaugural Rugby Championship will adopt the pitch-side concussion assessment (PSCA) method being phased into the sport for safety reasons.
SANZAR announced the four-nation competition kicking off on August 18 would join New Zealand's national provincial championship in trialling the protocols.
Any player who sustains a head injury with signs of concussion will be able to leave the field and be replaced for up to five minutes while an assessment is undertaken.
If a player passes the assessment, they can return to the field but, if a concussion is suspected, the replacement becomes permanent.
Players who cannot return are then expected to undertake further testing to fully diagnose any conditions.
SANZAR chief executive Greg Peters said player welfare was paramount.
"With players involved in the Rugby Championship playing against the best of the best, it is important that all measures be put in place to ensure player welfare and that we operate to best medical practice," Peters said in a statement.
The first step in a global initiative saw the PSCA trialled at the junior world championship in South Africa.
The Rugby Championship kicks off with a double-header when the Wallabies host the All Blacks in Sydney and the Springboks play the Pumas in Cape Town.