John Stamos is grieving the death of his mother.

The 'Necessary Roughness' star shared a picture of them together when he was baby, with the caption: "The love of my life passed away yesterday in her home surrounded by her children and grandchildren."

He added: "My mother had enough love to fuel a small country. She was truly one of a kind and will live forever in the hearts of all who knew her.

"A few weeks ago, I asked my mom if she remembered an inconsequential event - she simply replied, 'I only remember the love.' #Brokenhearted #Iloveyouthemost"

The former 'ER' star urged any followers eager to show their support to make donations to The Vanguard Cancer Foundation, the charity founded by his mother and described on its website as a not-for-profit, volunteer organisation advocating for more personalized and intelligent cancer care.

Loretta was inspired to start the charity after her brother was diagnosed with terminal cancer many years ago.

In a statement on the organisation's website, she wrote: "Thirteen years ago, I held my brother's hand as a doctor told him that his cancer was untreatable. As I think back to that moment, I realize just how many people would have accepted that diagnosis and given up. Thankfully, Jake knew better ... the Vanguard Cancer Foundation will be here, empowering patients to take the fight against cancer into their own hands."