One person has died after a campervan and a car crashed at Otaraia near Gore.
The accident happened at the intersection of Andrews Road and Old Coach Road at 4.30pm on Friday, police say.
A helicopter has taken one person to Dunedin Hospital. Their injuries are not thought to be life-threatening.
An ambulance has taken another person to Invercargill Hospital.
The serious crash unit is at the scene and diversions remain in place.