Warriors Coach Daniel Anderson
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Centre Brad Parker and second-rower Ben Trbojevic are both out for the game after the pair picked up concussions last week.
They join the likes of Christian Tuipulotu, Matthew Lodge and Karl Lawton in Manly's growing injury ward.
Coach Anthony Seibold explains the severity of their issues.
Kickoff at the Warriors' renamed home venue, the Daniel Anderson Stadium, is at 8.pm.
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