Mark Duplass relies on a "complicated system" to manage his depression

He told New York Post column PageSix: "It's a really complicated system of making sure you get enough sleep, making sure you get exercise every day, making sure I'm being really careful about the medication I take, never to miss it ... [My medication is] a very fundamental critical part of my system ...

"It's a delicate balance and ecosystem. I feel like I gotta make sure I keep showing up and working and it's exhausting sometimes, but what choice do I have?"

Mark previously opened up about his struggle back in 2023, posting a picture of himself on a red carpet and explaining how he is able to see the "fear and sadness" behind his smile.

He wrote: "I have been struggling with anxiety and depression for most of my life. Sometimes it's just a subtle feeling that something deep inside is wrong.

"Sometimes it's a little stronger, and it affects my ability to function properly.

"And sometimes it comes barging through my front door and pins me to the ground for an unknown and seemingly insurmountable amount of time.

"When I see pictures of myself like this one, I can see the fear and sadness behind the smile. Even at my most 'happy' times.

"But at times like these, when the world is so deeply terrifying and saddening, it's a struggle just to stay on my feet and keep from crashing. "

He added: "And this is from the perspective of someone with years of experience dealing with this and excellent support systems ... daily exercise, 8 hours of sleep, the right medication, a great therapist, a family who loves and supports me, the ability to eat healthy foods, etc.

" So I wanted to take a moment to send my love and support to all of you who may be dealing with something similar. I know we've heard all the platitudes before, but sometimes it's good to hear them again.

"You are not alone. There is help. This will pass ... "

In a post on the site earlier this week, Mark revealed he's been feeling better recently.

He wrote: "I've been feeling stronger lately. A little lighter, more inspired, more energy. Better in social situations and with my work capacity. Overall, just 'happier'.

"For those of you who deal with depression, it's like those moments when the mood fog lifts and you think : 'Oh, right, THIS is what it's like. I forgot'.

"Because I do forget. It's amazing how the herculean daily struggle to keep yourself from descending (exercise, diet, medication, therapy, meditation, sleep, journaling, etc) can become so routine.

"All just to keep yourself from drowning in the darkness. It can be exhausting and you don't even realize how hard you're working just to stay vertical."

He added: "I hope you're all finding silver linings. Little slivers of hope and joy. The small things. That morning coffee. The pet snuggles.

"A favorite song in your headphones at the grocery. A walk right before sunset. I hope you can feel the big, tidal wave of hope I'm sending your way."