George Clooney doesn't think an 'E.R.' reboot would fare as well as the original series

Asked about the possibility during a live virtual reunion of the ER cast on Stars in the House to support co-star Gloria Reuben's non-profit organisation, Waterkeeper Alliance, he said: "I don't know. The hardest part is that when you look at the show and consistently over so many years - it would be hard to say that you could do it at the level that we did it. I'm not sure that that's available."

George has been enjoying old episodes of the show recently with his wife Amal and praised the series as "such great television".

He gushed about the show's season one episode 'Love's Labor Lost': "This is better than anything I see in film or anywhere. This is stunning. It's stunning work.

"I felt that way about a lot of episodes I watched. I'm not sure [about a reboot]... it's hard to catch lightning again."

His former co-star Julianna Margulies agreed, insisting a reboot would "cheapen" the show's legacy.

The 54-year-old actress - who played Carol Hathaway - said: "You can't capture lightning in a bottle twice. I think you have to leave what was so beautiful and move on, because it just feels cheap... It would cheapen it for me."

However, Ming-Na Wen admitted she'd enjoy returning to play Jing-Mei Chen just because it would mean she could reconnect with the cast again.

She said during the reunion, which was streamed on People magazine's social channels: "I would love to reboot only to be able to hang out with this group of people, the talent.

"As you get older, the appreciation level and the awareness is so much greater. Just such great fortune. I would love to have been, even now... just even this, surrounded by these people."

George admitted he'd been "excited" about reconnecting for the virtual reunion.

He said: "I'm excited to see this gang. These are people that I really love, you know, and that - we grew up together, really grew up together, in many ways, and it's fun to see you guys."